Undifferentiated cell lines developed that exhibited diagnostic features of ES cells including colonization of multiple tissues in viable chimeras.
Indeed, stem cell systems should be nearly ideal for determining whether a compound will be toxic to a developing fetus, especially if researchers can recapitulate the biology of multiple tissues in a single culture.
In a recent study, Giordano et al. showed a much higher mitochondrial DNA content and increased mitochondrial biogenesis in multiple tissues in unaffected mutation (m.11778G>A) carriers, which differentiates the unaffected carries from LHON affected patients and healthy individuals (Giordano et al., 2014).
Pregnancy-associated traits and pathologies are further complicated by extensive communication across multiple tissues in two individuals, interactions between two genomes maternal and fetal that obscure causal variants and lead to genetic conflict, and rapid evolution of pregnancy-associated traits across mammals and in the human lineage.
We examined Comt expression in multiple tissues in over 100 diverse strains and several genetic crosses.
IGF-1a and IGF-2a mRNAs were detected in multiple tissues in adult fish.
zTERT is also significantly expressed during early development and also in multiple tissues in adult fish (Figure S3) [23].
We measured expression of Comt across multiple tissues in over 100 strains of mice and several large F2 intercrosses using four microrray platforms.
Consistent with this, as expected the target genes shared commonly among multiple tissues in each species are functionally enriched in cell cycle, DNA repair, and DNA replication.
Although mosaic abnormalities are increasingly considered to be important factors in (spontaneous) abortions [38], congenital anomalies [22], [39] [42] and in phenotypic variability, analysis of multiple tissues in prenatal cases is done only rarely.
The lack of available gene expression data from multiple tissues in PD patients at various stages of the disease prevents such an analysis but highlights the need for ongoing research efforts in this area.
