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Although gene expression differences between humans and chimpanzees in multiple tissues have been described [11] [14], the role of dietary differences on these expression differences awaits investigation.
Previous studies of Serial Analysis of Gene Expression (SAGE) in multiple tissues have shown significant physical clustering that was attributable to housekeeping genes rather than expression of tissue-specific transcripts [17].
In the case of the chicken, multiple tissues have been used for this type of eQTL analysis.
However, results from eQTL and whole-genome studies in multiple tissues have demonstrated that the genetic control of gene regulation often differs between tissues [ 18, 54].
Alternative approaches that jointly weight the probability of eQTLs across multiple tissues have been demonstrated to increase power to detect multi-tissue eQTLs [ 57].
Genome-wide patterns of correlation between expression of miRNAs and their target genes in multiple tissues have been less widely explored.
Similar(45)
However, an understanding of the evolution of gene expression regulation in primates across multiple tissues has not yet emerged.
These processes have previously been correlated to chronological aging by others [ 12, 53- 67], but interpreting the dynamics of biological functions throughout the lifespan in multiple tissues has been proved difficult so far.
For instance, a generalized inflammatory process affecting multiple tissues has been observed in several mouse models of LSDs, although its role in disease pathogenesis remains still largely unclear (Ballabio & Gieselmann, 2009).
However, a number of large-scale studies of multiple human tissues have identified vascular pericytes (which ensheathe capillaries and microvessels in all tissues) by immunohistochemistry, and then purified those to homogeneity by flow cytometry [ 9].
Studies exploring differences in gene expression in multiple primate tissues have yielded lists of genes, which are differentially expressed in closely related species (Khaitovich et al. 2005), but it is less clear which regulatory changes drive these differences.
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