Conversely, lower levels of TMEFF2 are found in multiple cancer tissues, especially in the malignant brain and colorectal samples, when compared to normal tissues.
First, MSCs have been shown to be able to migrate and engraft onto multiple musculoskeletal tissues, especially sites of injury, and undergo site-specific differentiation.
To achieve the strong phenotype of gene silencing, one frequently needs to generate different hairpin RNAi lines to trigger silencing of the same gene in multiple tissue types, especially during oogenesis (Ni et al. 2011).
MSCs have the capacity to engraft into multiple tissues in vivo, especially to sites of injury and inflammation, including primary tumor and tissue sites of metastasis.
The natriuretic peptides are a family of structurally related mediators with diverse autocrine/paracrine and endocrine functions in multiple tissues but they are especially involved in cardiovascular homeostasis [ 6, 31].
Multiple peptide identifications could belong to two or more isoforms and it is quite possible that several isoforms are present in the same sample, especially when multiple tissues are studied.
Both tissue-specific and common responses to CR are of potential importance, but common responses to CR across multiple tissue types provide especially attractive targets for further study.
This complex assortment of metabolic compounds is generated from and transported across multiple tissues, making evaluation of mechanistic data especially challenging (Caldwell JC et al. 2008).
FTO is widely expressed across multiple tissues, but is most highly expressed in brain and especially the hypothalamus [2], [16].
The complex interplay between genes and environment in NAFLD pathogenesis is sustained by multiple mechanisms that involve liver crosstalk with other organs and tissues, especially gut and adipose tissue.
