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In the former study, a key observation was that this is apparent in multiple tissues as well as in species other than humans.
Both TKO and DKO reconstituted mice also had altered frequencies of various leukocyte subsets in the thymus, bone marrow and spleen, displayed leukocyte infiltrates and autoimmune pathology in multiple tissues, as well as elevated levels of anti-nuclear autoantibodies.
As a result of this study, we recommend using "reference" data sets generated by real-time PCR to evaluate critical aspects of microarray platforms, including signal detection threshold, fold change correlation between pair-wise tissues, profile correlation across multiple tissues, as well as sensitivity and specificity in signal detection and differential expression.
Permanent and sometimes progressive changes in gene expression have been observed in multiple tissues as a consequence of IUGR [16], [17], [20], [21].
The causes of organismal aging are complex, and a variety of common processes have been implicated in multiple tissues as being involved in driving the decline in function seen with increasing age.
Mouse EpiSC are poorly compatible with embryo chimerism, at least by standard ES cell methods of blastocyst injection and morula aggregation, but retain the ability to differentiate to multiple tissues as judged by teratoma formation and in vitro differentiation [10], [11].
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This promoter directs transgene expression in multiple somatic tissues, as well as the testes [ 34].
As in current studies of human aging, future approaches in animal models must incorporate assessments of function in multiple tissues and organs, as well as measurements of integrative motor (strength, endurance, locomotion, etc).
Further, as activin A also induces fibrosis in multiple tissues, such as the lung, liver and kidney, it has the capacity to cause sub-optimal organ function, thereby contributing to poor survival [ 8, 11, 41].
Among these species, salamanders can be thought of as the 'champions of regeneration' because they are tetrapod vertebrates that can completely regenerate multiple tissues, such as the lens, ventricle and limb, and partially regenerate their intestine and spinal cord ([3 5], two examples of salamander species are shown in Fig. 1a b).
Vesl-2 (Homer 2) is a post-synaptic adaptor protein that has been shown to be present in multiple tissues such as brain and heart.
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