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S values for radioiodine in the mouse multiple thyroid models.
S values for radioiodine in the rat multiple thyroid models.
13550_2014_23_MOESM1_ESM.docx Additional file 1 S values for radioiodine in the mouse and rat multiple thyroid models.
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Two different models were developed in this work: 1) a single follicle model and 2) a multiple thyroid follicle model.
The calculated S values and the relative contributions to the mean absorbed dose to the inner follicle cell nuclei are presented in Table 2 with 123I, 125I and 131I homogeneously distributed within various source compartments (the follicle lumens and cells) in the human multiple thyroid follicle model (S values for the mouse and rat models, see Additional file 1).
Figure 2 Schematic illustration of the multiple thyroid follicle model.
A multiple thyroid follicle model was used to calculate the contribution from surrounding layers of follicles to the follicle cell nuclei in a centrally placed follicle, based on the previously published multiple follicle model [[19]].
The mean absorbed dose to the central follicle cell nuclei in the human multiple thyroid follicle model for different relations in radioiodine concentration (homogeneous in each compartment) between follicle lumens and/or follicle cells for (a 123I, (b 125I and (c 131I.
The multiple follicle thyroid model used in this work is a simplification, with a single spherical layer of follicle cells surrounding the central follicle and the neighbouring follicle lumen simulated as a spherical shell around the outer cell layer.
This recommendation should be applied to the largest thyroid nodule in cases of multiple thyroid nodules.
Multiple thyroid nodules were observed at that time.
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