These multifunctional, hybrid architectures possess better attributes for drug delivery such as high loading capacity, improved stability, ease of anchoring ligands, surface manipulation, tuneable drug release, loading multiple therapeutics, and excellent in vivo performance.
Lastly, multiple therapeutics that target FLT3 receptor (e.g., CEP701, PKC412, AB220) are in development for the treatment of AML.
Multiple therapeutics, including drugs, anti-inflammatory interleukin-10 gene therapy, antibiotics, and mesenchyme stromal cells, have been tested for efficacy in EVLP [32 35].
Mei, F. et al. Micropillar arrays as a high-throughput screening platform for therapeutics in multiple sclerosis.
Angiogenesis and VEGF have been confirmed as targets of anti-cancer therapeutics in multiple disease settings.
Multiple different therapeutics are in clinical development, so it is important to consider whether different therapeutic approaches lend themselves to specific oncogenic aberrations.
It is hoped that therapeutics in primary progressive multiple sclerosis will continue to expand and effective therapeutic agents will be developed.
Currently, there are multiple miRNA based replacement and inhibition therapeutics in the preclinical phase, along with Miravirsen, a phase II antiviral that targets miR-122 [ 7].
Specific inhibition of sPLA2 enzymes has an advantage over conventional RA therapeutics, in that it targets multiple possible pathways of RA pathogenesis, without affecting normally occurring biological processes.
As recovery following acute optic neuritis often is incomplete, with residual deficits in low-contrast vision, colour vision, vision-specific quality of life, and sometimes high-contrast visual acuity (HCVA) (Cole et al., 2000; Optic Neuritis Study Group, 2004, 2008 b ), more effective treatment of optic neuritis is itself an area of unmet need in multiple sclerosis therapeutics.
