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In order to deliver multiple therapeutic genes, an elastin-like polypeptide (ELP) based injectable system was designed.
Importantly, gradient transduction occurred in both lateral directions, thus enabling more advanced delivery studies that involve gradients of multiple therapeutic genes.
To our advantage, the GelMA/GO hydrogel based gene delivery system can be potentially used for codelivery of multiple therapeutic genes, bioactive small molecules and peptides.
Many biomedical applications require vectors that can direct the expression of multiple proteins; subunits of hetero-multimeric proteins, multiple therapeutic genes (combined and/or synergistic effects), or, simply, coexpression of a therapeutic protein along with proteins that act as (selectable) markers of transformed cells [ 1, 2].
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Interestingly, previous reports from diverse groups, among which ours, demonstrated that multiple therapeutic gene transfer might be necessary to promote optimal reparative activities in various cells of the musculoskeletal system (articular chondrocytes, MSCs) (Cucchiarini et al. 2009; Ikeda et al. 2004; Kim and Im 2011; Liu et al. 2013; Liu et al. 2015; Steinert et al. 2009; Tao et al. 2016).
There are multiple therapeutic agents that can be used for gram-negative infections.
The ability of nanomedicines to carry multiple therapeutic agents may increase their ability to improve treatment.
Multiple therapeutic agents, along with radiation and surgery, are the current standard therapeutic regimen for BCa patients.
Ongoing advances in our understanding of the pathophysiology of ALI/ARDS have revealed multiple therapeutic targets for gene-based approaches.
Using this improved procedure combined with the SEM system, we have constructed multiple marker-free oncolytic poxviruses expressing different cytokines and other therapeutic genes.
The current commercial techniques for activating therapeutic genes require the continual application of a drug to keep the gene active.
Related(11)
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