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Alpha levels were adjusted for multiple testing with step-down sequential Bonferroni correction where necessary.
Enrichment of each GO term was evaluated through use of the Fisher's exact Test and corrected for multiple testing with FDR [ 36].
c P-values were adjusted for multiple testing with the Benjamini-Hochberg method.
Spearman's correlation test, adjusted for multiple testing with Bonferroni correction, was used for analyzes of significant correlations between NRS pain and release of biomarkers at 140 minutes.
None of these results were significant after correction for multiple testing with FDR (q = 0.20).
This SNP remained significant after correction for multiple testing with FDR.
All specific haplotype effects discussed below were significant after correction for multiple testing with FDR (q = 0.2).
The ABCG2 polymorphism rs2231142 remained significantly associated with gout after correction for multiple testing with pcorr = 0.013.
Another potential reason for heterogeneity is the winner's curse, a manifestation of chance and regression-to-the-mean, especially under circumstances of multiple testing with limited power.
A correction was then applied in order to take into account the multiple testing; with this correction the statistical test was considered significant if below 0.0025.
All correlations were non-significant, even when omitting the correction for multiple testing, with very low values for the correlation coefficient (all p>0.05, uncorrected; median r = 0.04).
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