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Our results, that is, the detection of one SNP in SYPL2 remaining significantly associated with obesity after adjustment for multiple testing, support the notion that low-frequency and rare variants contribute to morbid obesity.
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Ranking the genes using a measure of their cluster density and correcting for multiple testing (Supporting Information S1) showed that the most significant among these was a cluster found in GRM1, the metabotropic glutamate receptor subtype 1 (mGluR1) (Figure 1C).
Statistical testing of these strains using the "common segment" method as described by Shao et al. (2010) using ANOVA with Dunnett correction for multiple testing supported the existence of each of these three QTLs (P < 0.05).
Multiple tests supported population expansions for each group of populations (boldface); one test supported a population bottleneck (underlined).
29 Multiple testing is supported as the goal is to improve design, not just document weaknesses and sampling as little as five users has been shown to uncover substantial problems.
However, access to multiple test results supports the creation of predictors that are more complex and hopefully more accurate, since they are based on the integrated results from more parameters.
Employing a single CpG look-up approach (one CpG evaluated, uncorrected for multiple testing), our data provide support for an association between maternal smoking during pregnancy and cord blood DNA methylation at this CpG (coef = –0.020, se = 0.009, p = 0.016).
Although these neutrality test results only show nominal significance (not corrected for multiple testing), we interpret them as further support for non-neutral evolution of regions identified by the previous FST results.
The support for one of these (E309K) was weak and did not survive correction for multiple testing (Table 2).
No multiple testing corrections were applied.
Adjustment for multiple testing was not done.
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