Findings were prioritized based on significance thresholds and consistency across different analyses, and accounted for multiple testing and prior knowledge.
The second advantage of the Bayesian approach is that it easily allows one to perform sensitivity analysis on model assumptions (see for example Briggs et al., 2006) and, in the multiple testing framework, on prior belief of the null (Westfall et al., 1997).
This disappointing aspect can be attributed to the use of traditional thresholds of significance, even after adjustment for multiple testing, which reflect over optimistic prior belief in the tested hypotheses [ Ioannidis, 2005].
All SNP Z-statistics per breed (Z i ) were corrected for multiple-testing prior to combining the values together.
By registering on the site, users can create private repositories for saving data and analyses; users can implement various 'filters' (see below) prior to statistical analysis to reduce the multiple testing burden by integrating relevant prior knowledge.
In addition to Fmo3, five other genes listed in Figure 7 exhibited marginally significant correlations prior to multiple testing adjustment (Ero11b, Serpina12, Hes6, Cyp2f2 and Cyp4a14) (0.063 < P < 0.108; see Fig. 9B 9F).
All of the susceptibility loci had consistent direction of effects with the case/control component of the replication samples reported in Barrett et al. [ 2] (ESM Table 5), and even with our over-conservative threshold for multiple testing, given the very strong prior information that these were true effects [ 2], ten loci remained significant after the adjustment for multiple testing.
a Statistics according to the Audic and Claverie test statistic A stringent p-value cutoff (p ≤ 0.001), not corrected for multiple tests, was employed prior to validation of changes in expression of a gene in response to androgen.
Only for broad consent did the change in rating approach statistical significance – and only when using the paired t-test prior to adjusting for multiple testing.
The second data set contains 6,913 loci that were not under selection in any of the outlier tests (prior to corrections for multiple testing), and is referred to as the "neutral data set".
Any athlete experiencing prolonged symptoms, specific deficits, or multiple concussions may require further cognitive testing prior to returning to swimming.
