Suggestions(1)
Exact(1)
However, it is also essential that further well designed clinical trials which utilise both child and parent proxy completed QoL measures are conducted and in particular head-to-head studies of different treatment packages with a broad range of outcomes over extended periods of time, with multiple testing points are required.
Similar(59)
To reduce the incidence of false positives that arise through spuriously low variance in multiple testing [47], segmentation points were accepted only if |rdiff|≥1.0.
As with any study that examines many different end points, multiple testing and as a consequence the potential for false-positive results can be a problem, especially with so many effect modifiers.
Since 11 intra-group comparisons were performed on the same subjects at the end of each session and 24 h thereafter, significance levels were adjusted for multiple testing at each respective time points.
However, the adjustment of the P-value was only partial, as it did not take into account multiple testing due to multiple time points.
No corrections for multiple testing were applied on time points and subgroup statistical comparisons.
No adjustment was made for multiple testing as all secondary end points were regarded as exploratory.
All p-values were corrected for the false-positives introduced by the multiple testing presented by many time points using Bonferroni correction and 10-3 waselecteded as the cut-off threshold for p-values.
Data analysis and presentation were performed in accordance with CONSORT and REMARK recommendations and did not include any multiple testing, variable selection, and cut point optimisation.
MetaMA package was used to perform a moderated t-test with a Benjamini Hochberg (BH) correction at a 0.01 % threshold (to take into account the multiple testing problem) to each time point compared with T0.
Moreover, we did not want to overlook consistent patterns in results across samples because of a stringent correction for multiple testing as such patterns may point to genuine effects, e.g. several SNPs with a P-value below 0.01 in the same gene or in both the children's and adults' sample.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.
Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com