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Since we applied multiple testing, p values are given after Bonferroni correction.
The membrane metalloendopeptidase gene (MME), was the most significant gene with nominal P value of 2.5 × 10−5, which survived Bonferroni correction for multiple testing (P = 0.019).
These associations remained significant after correction for multiple testing (p = 0.01).
This association remains significant even after correction for multiple testing (P = 0.036).
Associations with SBP and urine potassium remained significant after correction for multiple testing (p = 0.02 and p = 0.01 respectively).
Of the six ISL1-flanking SNPs, rs6869844 remained statistically significant after adjustment for multiple testing (P = 0.039 with Bonferroni correction for 30 SNPs).
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To account for multiple testing, p-values were corrected according to Hochberg's method.
Over-representation analysis was carried out using InnateDB's default methodology (hypergeometric algorithm, Benjamini-Hochberg multiple testing p-value correction) [54], [57].
In order to provide a correction for multiple testing, p-values were adjusted following the procedure by Benjamini et al. [48].
To correct for multiple testing, P-values were adjusted according to the Bonferroni-Holm procedure, which is less conservative than the standard Bonferroni correction.
The TTGGGGTAT haplotype showed the strongest association with BAV and surpassed the Bonferroni correction for multiple testing (p-value 2.926×10−6, OR 3.978).
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