The pre-ARDS samples had significant higher PI3, but lower HNE/PI3, than either the ARDS or the post-ARDS in pairwise comparisons after correction for multiple testing (Figure 2).
A consequence of this relationship between effect size and polymorphism was that power was generally insufficient to detect significant associations in a single population following correction for multiple testing (Figure 6).
11 out of 20 TFs listed in Figure 2 show significantly higher conservation in their correspondent structures in specific positions of TFBSs than those based on 10,000 randomized experiments (P < 0.05, after Bonferroni correction for multiple testing; Figure 3).
We found that 50 out of 77 (~65%) TFs bind DNA sequences that are significantly conserved in at least one structural property (ranging from one to twenty-six structural properties, a total of 356 pairs of TF-structure correspondences) (P < 0.05, after Bonferroni correction for multiple testing; Figure 1).
When attempting to validate Vyssoki's 26 findings using all-sex daily data in Victoria and Greece, we did not find any significant correlations between daily suicide rate and hours of daily sunshine after differencing for the effects of season and correcting for multiple testing (figure 2).
Very limited evidence of hotspots of trans-regulation was found on only SSC13 and SSC15 after correction for multiple tests (Figure 4).
The discrepancy was even higher after Bonferroni's correction for multiple tests (Figure 3), with 0 to 5.9% of significant outcomes for EW and 1.47 to 65.5% for Tajima's D. Furthermore, for Tajima's D, class II loci, in particular -DQA1 and to a lesser extent -DQB1 and -DRB1, exhibited higher proportions of significant outcomes than HLA-A, -B, -Cw and -DPB1.
Twenty post-hoc pairwise comparisons between centres were significant (probability level adjusted for multiple tests; Figure S5 in additional file 8).
These analyses resulted in 15 (oppositional), 8 (DSM-IV: inattentive), 6 (DSM-IV: hyperactive), and 5 (DSM-IV: total) significantly different pairs of study-centres (probability level adjusted for multiple tests; Figure S3 in additional file 4).
These analyses identified a single branch on the phylogeny as exhibiting strong evidence for protein-coding adaptation, the branch uniting Meg3-9, which represents the most recent maize-specific expansion event (p < 0.05 after correcting for multiple tests; Figure 2A).
