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A key advantage of these new task variants is the ability to give multiple test trials within a single session.
Following pretraining (see General Method), the rats received one session of a standard spontaneous object recognition protocol that contained multiple test trials.
Multiple test trials may be most feasible on land-based test beds, which have fewer logistical constraints than ships, and allow for more controlled and repeated sampling and analysis.
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However, to control for multiple testing, trials that are not stopped early generally require larger sample sizes compared with similarly designed non-sequential trials.
To control for multiple tests, trial sequential monitoring boundaries for both type 1 (5%) and type 2 (20%) error rates were established using O'Brien-Fleming adjustments [ 53, 54].
Episodic memory tests with multiple learning-test trials are more sensitive than those with single learning test trial for the diagnosis of MCI [ 4- 9].
The present study indicates further that an associative memory test with multiple learning-test trials is more powerful in amplifying the memory difference between aMCI and normal elderly.
Therefore, associative memory tasks with multiple learning-test trials may be particularly useful instruments for the detection of potential aMCI individuals.
Therefore, an associative memory test with multiple learning-test trials would be a very useful instrument for the detection of potential "early aMCI," a condition wherein elderly individuals' memory performance is between the normal stage and conventional aMCI [ 45].
17 TSA was also performed to quantify the reliability of data in meta-analysis adjusting significance levels for sparse data and multiple testing on accumulating trials.
Fleming's multiple-stage design [Fleming TR. One-sample multiple testing procedure for phase II clinical trials.
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