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Additional analogous tests presumably could be constructed to account for multiple test issues that might arise if we examined many trees [ 78].
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We use the q-value method developed by Storey et al. [25], [26] to deal with the multiple test issue.
To retain a maximum of power in the primary interesting analyses, no correction of alpha error rate in consideration of the multiple test issue was performed.
No correction of P values was applied to adjust for multiple test issue.
To consider multiple test issue within these analyses, the R-function 'maxstat.test' was employed (Hothorn and Zeileis, 2008).
A detailed statistical analysis plan (SAP) will be defined in advance to the final analysis, to fix detailed statistical considerations with regard to further data analyses, multiple test issue, missing value imputation and sensitivity analyses.
Since PCA can generate a single measure of intellectual performance, it sidesteps many of the multiple testing issues that arise in dealing with the full multiplicity of subtests.
Despite early concerns about multiple testing issues and power, GWA studies have brought the gene mapping successes for complex traits, which candidate gene studies were largely unable to deliver.
Importantly, the P-value threshold for significance is corrected for multiple testing issues.
It also helps prioritize tests of gene-gene interaction, which can limit multiple testing issues.
This analysis method avoids multiple testing issues and improves statistical power compared to the conventional approach.
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