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We use the q-value method developed by Storey et al. [25], [26] to deal with the multiple test issue.
To retain a maximum of power in the primary interesting analyses, no correction of alpha error rate in consideration of the multiple test issue was performed.
No correction of P values was applied to adjust for multiple test issue.
To consider multiple test issue within these analyses, the R-function 'maxstat.test' was employed (Hothorn and Zeileis, 2008).
A detailed statistical analysis plan (SAP) will be defined in advance to the final analysis, to fix detailed statistical considerations with regard to further data analyses, multiple test issue, missing value imputation and sensitivity analyses.
Similar(55)
Additional analogous tests presumably could be constructed to account for multiple test issues that might arise if we examined many trees [ 78].
SnPM was chosen to deal with the multiple testing issue which arises when considering simultaneous testing on either dense electrode arrays, voxels or between-hubs connectivities as it is a simple yet robust approach to control for type I statistical errors (i.e. rejection of a true null-hypothesis).
This inherent bias could be accounted for to an extent by correcting for the multiple testing issue.
The latter is not surprising, since both FAM-MDR* and PGMDR completely ignore the multiple testing issue.
FAM-MDR is found to outperform PGMDR in that it handles the multiple testing issue more correctly, has increased power, and efficiently uses all available information.
Different SNP window sizes could be tried but this would raise a multiple testing issue.
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