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This p-value would correspond to a multiple test corrected p≈0.05.
The apparent lack of response in seven instances (see Results) is a subthreshold phenomenon caused by a conservative multiple test corrected thresholding, and does not mean that the experiment failed in these cases.
In these, the display threshold for bird- and hemispheric-averaged activations was set to p = 10−6 (multiple test corrected using Gaussian random field theory and taking the n = 8 birds per group into account).
Benjamini-Hochberg multiple test corrected p values are shown only.
Multiple test corrected P < 0.05 was used to define enrichment/depletion.
All miRNAs have multiple test corrected p < 10-16 in terms of their association with COL11A1.
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FTO-SNP rs1121980 rendered the lowest nominal p-value of 1.13×10−7; this SNP was the only SNP that survived correction for multiple testing (corrected p = 0.0494; Table 1).
The multiple testing corrected P-values (Benjamini correction) are reported.
We identified four regions which showed an excess of deletions in controls, but these regions did not remain significant after correction for multiple testing (corrected P > 0.4).
We therefore performed an FDR correction using "p.adjust" and provided the list of multiple testing corrected p-values in the additional files (Additional file 1).
The negative log of the multiple testing corrected best p-value is a score for the subset pair.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com