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7 The alignment between the target and the multiple templates were manually edited to obtain the best optimal alignment.
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These results correlate well with previous models of biosilicification and suggest that the use of multiple templates is a suitable approach to elaborate more complex silica architectures.
During template preparation mixed clusters occur whenever multiple templates are colocated [ 15].
In total, roughly 45% of the targets that a model created from multiple templates are better than the best single-template model.
The test set for modelling multiple templates is a subset of the above set and contains targets associated with at least two templates.
Making a method available that can readily use multiple templates is of great importance, particularly since there is not an abundance of such methods available as web servers.
However, one problem when using multiple templates is that sometimes the different alignments contain contradictory information, which results in convergence problems.
These samples were sequenced with the MY 09/11 primers; five had either degenerated in storage or would not amplify, two contained multiple templates and were impossible to sequence, while four were successfully sequenced and identified but none were infected with novel types, merely types not included in the ELISA probe cocktail (Table 2).
Subsequently, multiple other circular templates were interlocked to the padlock probe by means of complementary sequence forming an ABABAB-type DNA copolymer (Fig. 7A).
The model with the highest confidence score (C-score: a scoring function based on the relative clustering structural density and the consensus significance score of multiple threading templates) was considered as the best model.
If the shape of leaves within a species varies substantially, multiple leaf templates are suggested for creating the species leaf model.
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