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During template preparation mixed clusters occur whenever multiple templates are colocated [ 15].
In total, roughly 45% of the targets that a model created from multiple templates are better than the best single-template model.
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These results correlate well with previous models of biosilicification and suggest that the use of multiple templates is a suitable approach to elaborate more complex silica architectures.
7 The alignment between the target and the multiple templates were manually edited to obtain the best optimal alignment.
The test set for modelling multiple templates is a subset of the above set and contains targets associated with at least two templates.
Making a method available that can readily use multiple templates is of great importance, particularly since there is not an abundance of such methods available as web servers.
However, one problem when using multiple templates is that sometimes the different alignments contain contradictory information, which results in convergence problems.
If the shape of leaves within a species varies substantially, multiple leaf templates are suggested for creating the species leaf model.
In [16 18] multiple-view templates are used to represent faces with different poses.
Multiple secondary structure templates are also used, if possible, to aid in the modelling of the specific target sequence.
In this process, sequences of multiple known structures, "templates", are compared to the OB-fold domain sequence of the α subunit (residues 978−1078).
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