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NSC37168 also binds multiple targets within different cell types [3, 35].
This reinforces the belief that drug molecules, at least partly, work by interfering with the function of multiple targets within the cellular milieu.
For example, the photostability, narrow emission peak, and ability to rationally modify both the size and surface chemistry of Quantum Dots allow for simultaneous analyses of multiple targets within the same cell.
We discuss the genetic organization of microRNAs and how that architecture is designed to regulate multiple targets within regulatory pathways, and their role in adaptive regulation in response to changes in the microenvironment.
Triad's approach, called Integrated Object-oriented PharmacoEngIOPE™ing (IOPE™), focuses on designing inhibitors for entire protein families, such as oxidoreductases and kinases, thereby enabling parallel discovery of inhibitors for multiple targets within a protein family.
Apart from its effect on the cyclic GMP system, NO is known to affect multiple targets within the cell, mainly acting through S-nitrosylation [33], [34], [35], [36].
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However, they assume that each sensor can only monitor one target object at any moment even if multiple targets fall within the sensing area of a sensor.
Most of the known miRNA in Arabidopsis are thought to have multiple targets often within the same family of homologous proteins[ 22].
Examining microRNAs with degree greater than two in any signalling pathway, we were able to identify 77 microRNAs that act only in an intra-pathway manner, affecting multiple targets but only within one single pathway.
Instead, the amplification profiles are complex and multi-modal, suggesting that multiple targets may coexist within these regions.
Hence, the frequency-domain radar process is able to operate for multiple target scenarios within appropriate resolution.
Related(20)
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