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Therefore, significant effort has been devoted to designing multifunctional metal-chelators aiming at multiple targets that must be addressed in these neurodegenerative diseases.
MiR-29 has multiple targets that may affect neuronal growth (Govek et al., 2005; Wang et al., 2013).
This method has been used to analyze multiple targets that are important in microbial infections (20, 21 ).
They are also phytotoxic by blocking the electron transport chain in thylakoids at multiple targets that are different from those of current herbicides.
As this miRNA negatively regulates multiple targets that are involved in inhibiting anoikis, miR-26a makes an ideal candidate for therapeutic approach for liver cancer.
This would suggest that either it has multiple targets that are expressed in a cell-specific manner or a target that affects cell-specific pathways.
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Hallmarks of attacks linked to the Haqqani network include multiple fighters, targets that are often symbols of the Afghan government and their Western backers, careful planning, and, often, instructions delivered by telephone as the attackers carry out their mission.
During these moments, players are directed against multiple aerial targets that must be destroyed in order to win.
Akt activation can stimulate proliferation through multiple downstream targets that affect cell-cycle regulation [ 63].
There is no straightforward method to confirm functional inhibition of NKG2D as this receptor has multiple downstream targets that are shared with other pathways.
A notable example is that pyruvate, the metabolite target for enhancing succinate production, was found to be associated with multiple reaction targets that were only identifiable through more computationally expensive means.
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