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It is well established that the re-use of protein motifs in natural (and directed ) evolution means that most drugs, especially the more lipophilic ones, are promiscuous in the sense that they bind to multiple targets (on average six known ones for marketed drugs ).
The development of neoantigen vaccines, which are tailored to seek out multiple targets on an individual's tumour, is progressing rapidly.
This raises the possibility of multiple targets on each trial.
The problem of tracking multiple targets on a plane using the superposition of their received signal strengths as measurements has been investigated.
There's also a great feature called Dead Eye Mode‚ where you hold down R2, the game slips into slo-mo and you can place as many as 15 multiple targets on your enemies.
These results suggest that broad specificity of polyclonal IgG may be related to multiple targets on multiple myeloma cells.
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The authors argue that the effects of multiple targeting on correlation based inference may not be as serious/prevalent as is suggested in a recent paper by Okoniewski and Miller.
2. Klebanov et al. point out two problems with the Novartis Gene Atlas dataset and analysis used by Okoniewski and Miller to assess the effects of multiple targeting on correlation analysis.
As shown, the distinct separation in the optical absorption spectrum between GNRs with different ARs enables the multiple targeting on the same site with an insignificant overlap between two different wavelengths.
Results from this study revealed that multiple targeting on a gene could also act together to provide enhanced mRNA decay rate, and hence stronger gene repression, which could contribute to facilitate the transition of miRNA target genes to new expression programs.
A traditional Chinese medicine (TCM) preparation contains various active ingredients that exhibit synergistic effects on multiple targets to treat disease.
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