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If there are multiple targets involved, then the work becomes even harder.
By testing a small set of miR-181 targets in the reprogramming, Judson et al. then showed that miR-181, much like miR-294/302, represses multiple targets involved in the EMT, cell death, cell cycle, and mitochondria function.
The single target docking cannot capture the biological effects of the ligands comprehensively, and the multi-target docking is really necessary to characterize the complicated binding process of ligands with multiple targets involved in biological network.
These events were associated with TGFBR3-regulated multiple targets involved in CNE-2Z proliferation.
Numerous miRNAs are dysregulated in cancers, and a single miRNA can have multiple targets involved in different oncogenic pathways.
Reverse transcription PCR, western blot and activity assays were performed to assess whether enzastaurin influenced thymidylate synthase (TS) and the expression of multiple targets involved in cancer signaling and cell cycle distribution.
Similar(52)
However, tracking multiple targets involves assignment problems because of miss detections and false alarms.
Corresponding to the complexity of the components in diverse herbs or even in one herb, herbal medicines hit multiple biological targets involved in various pathogenesis.
The data presented here suggest that there are multiple circadian targets involved in regulating the day-night difference in urination behavior, including the bladder itself.
It transactivates multiple gene targets involved in cellular anti-oxidant defense, including SOD2 [ 38], and is also a central regulator of endochondral ossification and articular cartilage matrix homeostasis [ 39, 40, 60].
MicroRNAs (miRNAs or miRs) are a class of small non-coding RNAs that exert pleiotropic effects by post-transcriptionally regulating multiple transcript targets involved in distinct cellular processes in both normal and pathological conditions.
More suggestions(15)
multiple sites involved
multiple centres involved
multiple observations involved
multiple mechanisms involved
multiple steps involved
multiple pathways involved
multiple alleles involved
multiple interactions involved
multiple tradeoffs involved
multiple players involved
multiple reasons involved
multiple ironies involved
multiple genes involved
multiple aspects involved
multiple arteries involved
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