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Moreover, DATS inhibited cell growth of A375 and BCC cells via activation of multiple target pathways.
Owing to multiple target pathways, the therapeutic potential of CsA is limited, in particular during long-term treatment, because it has several side-effects, such as hepatotoxicity, nephrotoxicity, neurotoxicity and cytotoxicity [24].
These results may suggest that resveratrol acts via multiple target pathways, and as such, calculating the effective in vivo concentration of resveratrol or designing new studies based on current literature is challenging.
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Many of these dietary compounds appear to act on multiple target signaling pathways.
Thus, miR-101 will probably become a therapeutic agent to target DNA repair genes and enhance the effects of radiation mediated through multiple targets and pathways [ 32].
It is likely that this will require a combination of cellular therapies and the development of pharmaceutical agents addressing multiple targets in pathways involved in fibrogenesis.
Such therapies, including multi-component drugs or multi-targeting drugs, may produce concerted pharmacological intervention of multiple targets and signaling pathways that drive the growth of tumors.
5 A single miRNA can manipulate multiple target gene expressions, initiate signaling pathways, and provoke signal crosstalk.
Based on Cur ability to affect multiple targets, other signaling pathways might be involved.
It acts on multiple targets in cellular pathways making this agent able to perform multiple actions [ 7].
These could be the result of a multiple targeting of different pathways on endothelial cells as well as on tumor cells.
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