Sentence examples for multiple target networks from inspiring English sources
For instance, clozapine is the "gold standard" anti-psychotic drug exhibiting beneficial effects via complicated interactions with multiple target networks [4].
MicroRNAs (miRNAs) coordinately regulate multiple targets within signaling networks, making them attractive candidate HSC regulators.
The large number of miRNA genes combined with the potential of each miRNA to regulate multiple target mRNAs, implies a regulatory network of great complexity.
The dysregulation of regulatory networks can affect multiple target genes, thereby providing a molecular explanation for broad (pleiotropic) phenotypic differences.
However, understanding the mode of action of phenotypic screening hits can prove challenging since many drugs act by modulation of multiple intracellular targets ("network pharmacology") [9].
It is worth noting, however, that it is possible that addressing multiple targets within the network underlying AD pathophysiology may be successful even when each target is affected in a relatively modest way; in other words, the effects of the various targets may be additive, multiplicative, or otherwise synergistic.
Network biology gives further insight into the importance of a multiple target approach to override compensatory mechanisms [ 5].
Multiple Target Ligand Database.
Then we convert this tree into the Prufer sequence and embed it in the confidential packet for multicast, which is equivalent to multicasting the packet to multiple targets over a multihop network.
Conceptually, multi-target drugs work by creating a combination effect on multiple targets in the biological network simultaneously, which may (through e.g. synergistic effects) decrease the therapeutic dose required, thus increasing therapeutic efficacy, preventing drug resistance, and reducing target-related adverse effects [12 14].
