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First, we identified some SNPs associated with multiple target miRNAs.
The results showed that, similar to the majority of the pol II genes, one miRNA can be regulated by different TFs (Table S2.1) and one specific TF can modulate the expression of multiple target miRNAs (Table S2.2).
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By using the approach described above, we investigated the regulation of p21 by its multiple targeting miRNAs.
Most miRNAs are able to target multiple target mRNAs and most mRNAs are targeted by multiple miRNAs, making research on the function of miRNAs a complex endeavor.
Even though multiple target mRNAs can be detected, miRNA may regulate specific mRNAs at specific times and at specific sites.
Work to identify the multiple targets of miRNAs is still in its infancy, and a clear distinction between siRNAs and miRNAs is difficult in some instances.
This investigation has been motivated by previous observations suggesting that the mRNA degradation following binding of miRNA is more efficient for transcripts carrying multiple target sites for miRNAs [32] [34].
This downreguation of miRNA regulated genes is particularly noticeable for genes carrying multiple target sites for miRNAs.
Most miRNA targets that are conserved in different plant species also have miRNA families with multiple target sites, suggesting that these miRNAs are functionally divergent.
Most miRNA families have multiple target sites, suggesting that these miRNAs are functionally divergent.
And most miRNA families have multiple target sites, suggesting that these miRNAs are functionally divergent.
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CEO of Professional Science Editing for Scientists @ prosciediting.com