CRISPRi can be used to repress multiple target genes simultaneously, and its effects are reversible.
MicroRNA is an endogenous, small RNA controlling multiple target genes and playing roles in various biological processes including tumorigenesis.
dCas9 TV confers far stronger transcriptional activation of single or multiple target genes than the routinely used dCas9 VP64 activator in both plant and mammalian cells.
The bead array technology allows simultaneous detection of multiple target genes in a single sample, reducing time, labor and cost.
We postulate that combinatorial 'cis-trans engineering' using a CRISPR-dCas9-based bipartite module could be used to regulate the expression of multiple target genes.
The miRNA microarrays revealed that 18 differentially-expressed miRNAs on microgrooved pattern had multiple target genes, contributing comprehensively to the cellular regulation process.
scRNA enables simultaneous multidirectional regulation of multiple target genes.
A single miRNA can downregulate the expression of multiple target genes and thereby inhibit tumor metastasis.
A single miRNA can downregulate the expression of multiple target genes, thereby coordinately inhibiting or promoting tumor metastasis.
A key feature of the most widely studied Wnt signaling cascade is the stabilization of cytosolic beta-catenin, resulting in beta-catenin nuclear translocation and transcriptional activation of multiple target genes.
MicroRNAs (miRNAs) are short, noncoding RNAs that regulate the expression of multiple target genes.
