Sentence examples for multiple target effectors from inspiring English sources
This finding is consistent with the notion that PKN is just one of multiple target effectors that function downstream of Rho1 in any given process or tissue, especially one that would involve a diverse array of responses as needed during wing morphogenesis.
This suggested that all the effectors identified operate through control of multiple target genes to alter the phenotype under study, most probably through the promiscuous nature of the RNAi/miRNA machinery in mammalian cells [41], [42].
The actions of RhoA are mediated by Rho effectors such as p160ROCK (Rho-kinase) which can phosphorylate multiple target proteins.
Multiple Target Ligand Database.
The PI3K-pathway activates multiple targets including AKT and its downstream effector mammalian target of rapamycin (mTOR) [7], [8], thus promoting cell growth and survival by suppression of apoptosis and modulation of glucose uptake and cellular metabolism [9].
Instead, a combination of therapies targeting multiple effectors will likely be necessary.
Multiple targets of miR-510 are predicted to directly target multiple negative regulators and effectors of the Akt signaling pathway and, therefore, a potential mechanism of miR-510-mediated increase in cell proliferation, migration, invasion and tumor growth could be through hyperactivation of the Akt signaling pathway.
Studies conducted in mammals and Drosophila have suggested that the downstream effectors of the Hippo pathway, YAP/TAZ and Yki direct expression of multiple targets linking cell division and cell death.
The integrative approach using random small RNA libraries and cell-based genetic selection provides a novel technology platform for identifying RNA effectors capable of modifying complex cellular phenotypes through control of the expression level of multiple targets.
But multiple targets could prove confusing.
