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It may relate to the recognition of multiple target antigens on the surface of EB in the i.n.n
Incorporating multiple target antigens allows the vaccine to attack cancer cells through multiple avenues and potentially reduces the chance for cancer cells to escape the therapy.
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Therefore, the same technology as well as the proposed integrated experimental and modeling approach can be used to target either multiple types of cancer cells, or to include multiple targeting antigens for the same cell on one microparticle.
Through reduced off-rates, which result from multiple binding to two target antigens and to rebinding when one Fv dissociates, the diabody is suitable to facilitate specific agglutination of bacteria.
When investigational products are evaluated in multiple tumor types with confirmed target antigens, differences in toxicity between the tumor types remain poorly understood: thus, the tumor types may not be specified for planning phase I studies.
In summary, we demonstrate that a subset of patients with multiple sclerosis develops disease-associated demyelinating and axopathic autoantibody responses that target antigens expressed by highly differentiated myelinating oligodendrocytes.
Firstly, the high specificity and affinity of intrabodies to target antigens is well-established, whereas iRNA has been frequently shown to exert multiple non-specific effects.
Multiple Target Ligand Database.
Multiple Target Ligands.
Target antigens were identified by mass spectrometry.
There is now increasing recognition that a malaria vaccine may need to contain multiple variants of the target antigen to be effective against an entire parasite population [7].
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