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ApoE has multiple systemic functions, some of which relate to novel LOAD risk genes, which may also affect the aetiology of AD independently of Aß.
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It is plausible that the induction of HO-1 only occurs in local tissue and may not necessarily stand out from measuring circulating bilirubin level, since serum bilirubin level is affected by multiple systemic factors including liver function.
EVs play a pivotal role in the regulation of multiple systemic pathophysiological processes.
The aim of the study was to show the multiple systemic effects of cachexia in pancreatic cancer patients, in terms of resection rate, effects on pulmonary function, amount of fat and muscle tissue, as well as changes in laboratory parameters.
"Multiple systemic factors" were creating a "pressure for increasing rates of diagnosis and medication".
Subject 3 had the most number of previous treatments including multiple systemic treatments and multiple biologic therapies.
The multiple systemic defects in Adam17ΔZn/ΔZn mice also support this hypothesis [17].
Multiple systemic reviews have been published recently.
Thus, multiple systemic LPS challenges may prime microglia despite no longer stimulating systemic inflammation.
Cardiac mIGF-1/SIRT1 signaling may thus modulate disparate systemic functions.
Policy reform emphasising recharge can contribute to water security and yield socio-economic outcomes through a systemic understanding of how the water system functions, and by connecting goals and budgets across multiple, currently fragmented policy areas.
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