Activation of sod‐1 and prdx‐2 by Mianserin was abolished in multiple synaptic transmission mutants, including unc‐26 e205), snt‐1 md290), snb‐1 md247), unc‐18 e81), and unc‐2 e55) (Fig. 3E), strains that have slowed or abolished synaptic transmission.
Synapsins (Syns) are synaptic vesicle (SV) phosphoproteins that play multiple roles in synaptic transmission and plasticity (1).
Therefore, it is likely that IGF-1R signaling affects multiple aspects of synaptic transmission, some of which are tau-independent.
Synapsin I (SynI) is a synaptic vesicle (SV) phosphoprotein playing multiple roles in synaptic transmission and plasticity by differentially affecting crucial steps of SV trafficking in excitatory and inhibitory synapses.
It is worth mentioning, however, that neural fields involving multiple synaptic time scales are sensitive to transmission delays [33].
Thus, the specific localization of Zn2+ at certain glutamatergic synapses, together with its multiple synaptic targets, makes the cation a very attractive candidate as an endogenous modulator of synaptic transmission and plasticity; however, deregulated Zn2+ homeostasis also appears to be a strong promoter of AD development.
Most approaches to brain function consider neuronal firings and synaptic transmissions as fundamental information states (e.g. 'bits') in computational networks of neurons.
The different effects of leptin on excitatory synaptic transmissions indicate that leptin actions on synaptic transmission are probably developmentally regulated.
In practice, the delay in some NNs is due to multiple factors (e.g., synaptic transmission delay, neuroaxon transmission delay); one natural paradigm for treating it is to use a probabilistic description (see, e.g., [17, 18, 24, 25]).
Complex interactions between multiple cellular components underlie synaptic transmission, a process that occurs with speed, precision and plasticity for extended periods of time.
