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The VTA dopamine neurons stimulated by the mice do not connect directly to the OFC or the dorsal striatum, so the link between these regions must involve multiple synaptic connections.
These observations are congruent, since bigger motoneurons generally innervate more muscle fibers [28], and support the popular hypothesis that motoneurons are specifically lost in ALS due to the burden of maintaining large somas, long axons, and multiple synaptic connections with muscle fibers.
In vivo experiments suggest differential sensitivity between supraspinal and spinal sites with the supra being more sensitive possibly because multiple synaptic connections are more sensitive to opioid than oligosynaptic ones [ 20].
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The nanostructured array platform was shown to be able to record and stimulate neuronal activity and map multiple individual synaptic connections.
Consistent with this idea, we found that neurons located in a thin laminar zone at the L3/5A border in the forelimb area of mouse M1 have multiple L4-like synaptic connections: excitatory input from thalamus, largely unidirectional excitatory outputs to L2/3 pyramidal neurons, and relatively weak long-range corticocortical inputs and outputs.
The synaptic connectivity matrix represents synaptic connections between 71 neurons and 8 effectors.
The correct patterning of synaptic connections, prevention of multiple contacts and control of nerve growth require AChR-mediated activity.
The two motor neurons appear to be functionally connected, possibly involving synaptic connections between them, although we cannot exclude the possibility of multiple neurons being engaged in their functional connections.
To test the stereotypy of synaptic connections, we compared patterns of connectivity between the two individuals.
These results support the hypothesis that memory consolidation is not a continuous process, but it rather relies on multiple and recurrent waves of protein synthesis to reinforce synaptic connections or to grow new ones [23].
Synaptic plasticity involves the modulation of synaptic connections in response to neuronal activity via multiple pathways.
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