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We propose that postsynaptic Lola functions as a transcription factor that controls synapse formation and/or maturation by regulating the expression of multiple synaptic components.
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Thus, lola is a potential candidate gene that may control synaptic function by coordinating transcription of multiple post-synaptic components.
Although it was not possible to estimate the electrotonic distance between the synapses and their total number, or to attribute the groups of synapses to the components of a composite EPSC, the labelling experiments suggested that multiple synaptic contacts between an SG EIN and a postsynaptic neuron can form the anatomical basis for the composite EPSCs.
However, it is unclear how glutamate dysregulation arises and which synaptic components are involved.
Rapsyn is required for MuSK signaling and recruits synaptic components to a MuSK-containing scaffold.
However, far less is known about the molecular pathways involved in redistribution of muscle synaptic components.
In this study, a compartment model of KC was constructed and simulated for the multiple synaptic inputs.
It is worth mentioning, however, that neural fields involving multiple synaptic time scales are sensitive to transmission delays [33].
Presynaptic terminals contain multiple synaptic vesicles, which release neurotransmitter [1].
We have found that synaptic components assemble at fixed sites that are much more stable than the components themselves.
These structural differences might be derived from differences of synaptic components.
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