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Multiple synaptic boutons contacting the target muscle cell are visible as yellow varicosities (scale bar = 10 μm).
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Individual callosal axons were found to terminate in multiple discrete clusters of synaptic boutons, presumably corresponding to cortical columns [15].
The terminal boutons are also unusual in that they are densely packed with vesicles and make multiple synaptic contacts with the post-synaptic cell [60].
Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins.
As a model, we suggest that the filamentous network around synaptic boutons restrains the spreading of synaptic branches.
Studies of ultrastructural dfmr mutant neurons reveal enlarged and irregular synaptic boutons with dense accumulation of synaptic vesicles.
The distribution of parallel fiber synaptic boutons was also not changed.
Gain-of-function experiments show that the presynaptic dose of DVAP-33A tightly modulates the number of synaptic boutons.
In mical mutants, synaptic boutons do not sprout normally over the muscle surface and tend to form clusters along synaptic branches and at nerve entry sites.
*See related Report: Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins.
Herein, we provide evidence for calretinin immunoreactive neurons and synaptic boutons in the ventral CN, axons in the trapezoid body, peridendritic boutons in the medial superior olive and calyceal endings in the medial nucleus of the trapezoid body (MNTB).
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