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Parallel fibers make multiple synapses on the dendritic trees and cell bodies of cerebellular Purkinje neurons.
Its axon forms multiple synapses on the soma and dendrites of a postsynaptic neuron.
Therefore, formation of multiple synapses on a postsynaptic neuron appears to be a general property of an SG EIN.
Analysis of composite EPSCs, computer simulations and labelling experiments indicated that the axon of an SG EIN forms multiple synapses on a postsynaptic neuron.
If lack of activity impairs retrograde signaling required to prevent the formation of multiple synapses on the same myofiber, fibers could present several fully innervated endplates.
Moreover, being close to several dendritic branches, many individual axonal terminals at DCCs made multiple synapses on different branches (Figure 6h).
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It is concluded that the multiple synapses of an SG EIN on a postsynaptic neuron increase efficacy of transmission and provide basis for diverse forms of plasticity.
We conclude that the multiple synapses formed by an SG EIN on a postsynaptic neuron increase synaptic excitation and provide basis for diverse forms of plasticity.
Thus, paired recordings, computer simulation and biocytin labelling indicated that the majority of the monosynaptic EPSCs are likely to be generated by transmitter release in multiple synapses formed by the axon of an SG EIN on a postsynaptic neuron.
Therefore, an existence of multiple synapses between the neurons is likely explanation for the composite EPSC.
The true number of EINs forming multiple synapses may be even higher.
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