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This finding stresses the point that the inheritance of autoimmune diseases are most probably due to multiple susceptible genes and also to environmental factors.
Furthermore, the fact that there are multiple susceptible genes that predispose to Lynch syndrome, immunohistochemistry and/or MSI should be used, where possible, as a pre-screening method to successfully identify the high risk families.
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We speculate that multiple gene mutation or some susceptible genes may be involved in the simultaneous occurrence of both malignancies.
To delay or prevent insect pests from evolving resistance to Bt crops, the U.S. Environmental Protection Agency promotes the use of multiple Bt genes in plants and the practice of growing refuges of non-Bt plants that serve as a reservoir for insects with Bt susceptible genes.
Hypertension is a multifactorial and polygenic disorder where several susceptible genes interact with the environmental factors.
Genes related to the susceptible loci are considered susceptible genes of the YZ constitution.
Another new susceptible gene therefore needs to be identified.
There is emerging evidence that each tumor may harbor multiple genes susceptible to promoter hypermethylation.
It has become apparent that pathogens often exploit essential cellular processes of their hosts for their own benefit during infection and that multiple host genes may be required to permit a susceptible infection [ 22].
It is believed that these complex traits are controlled by multiple genes and are susceptible to environmental changes [ 9, 12].
The focus of his research is on susceptible sub-populations such as young children, the elderly and those who carry susceptibility genes.
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