Sentence examples for multiple survival pathways from inspiring English sources
There is accumulating evidence revealing that GSC resilience is because of concomitant activation of multiple survival pathways.
AKT acts downstream of phosphatidylinositol 3-kinase (PI3K) signaling and is a key regulator of multiple survival pathways.
Even though many of these new drugs have shown little activity as single agents, the simultaneous targeting of multiple survival pathways and the tumor microenvironment through rationally designed treatment combinations could further enhance their activity.
Here, we provide in vitro evidence showing the activation of apoptosis and modulation of multiple survival pathways in established malignant T-cell lines and a primary T-cell lymphoma patient sample, which may underlie the efficacy of romidepsin.
While primary mammary cells appear to use mainly MAPK for survival, both in response to EGF as well as to IGF-1 [ 1], tumor cells might use multiple survival pathways that could impinge on BAD.
Whether CD44 expression plays a direct role in drug resistance by activating multiple survival pathways via growth factor receptors or integrin-mediated 'inside-out' signaling is not known and warrants further investigation.
Since Jak2 is capable of phosphorylating a number of downstream targets such as Stat1, Stat3 and Stat5, the effect of AG490 on platinum sensitivity in our model may be the result of inhibiting multiple survival signalling pathways.
Those events especially lead to dysregulated apoptosis and constitutively activation of multiple cell survival pathways.
It is important to note that FAK has many binding partners and integrates multiple oncogenic survival pathways and sequesters tumor-suppressor pathways [ 1, 22].
Combination therapy might promote synergistic effects leading to low drug dosage, as well as suppresses resistance to therapy if multiple cell survival pathways are targeted at once though there are chances of higher toxicity.
In addition, the complex tumor microenvironment and the presence of multiple redundant survival pathways at the primary tumor site may reduce the effect of glucosamine and compensate the pAkt activation.
