Many essential biological processes are mediated by complex molecular machines comprising multiple subunits.
Particularly, multiple subunits in complexes III and IV require heme as a prosthetic group, and different forms of heme are present (Fig. 3) [121].
Knockdown of UBLCP1 enhances proteasome activity in cells, while in vitro UBLCP1 directly dephosphorylates multiple subunits of purified 26S proteasome and reduces its activity.
Proteomic analysis showed that multiple subunits of respiratory complex IV were down-regulated in SIRT3-OE cells, which compromised the integrity and assembly of respiratory complexes, leading to over-production of ROS (Fig. 1D).
Starch is synthesized by four enzyme classes, with multiple subunits in each class: ADP-glucose pyrophosphorylase (AGPase); starch synthase (SS); starch branching enzyme (BE); and starch debranching enzyme (DBE).
The enzyme is divided into two sectors, each containing multiple subunits.
It is composed of multiple subunits organized into three regions; the head, middle, and tail.
For unknown reasons, multiple subunits within a given chromatin-associated complex are often targeted by sumoylation [33], [34].
Taste receptor cells (TRCs) in the circumvallate papillae express multiple subunits of the GABAA and GABAB receptors as well as multiple GATs.
This overlapping and redundant approach with multiple antibodies and immunoblots, against multiple subunits predicted to be hexameric, generated a high degree of confidence in the final measurements.
Molecular cloning of PI-3 kinases revealed a large and complex family that contains three classes with multiple subunits and isoforms [11], [12], [13], [14].
