Sentence examples for multiple substitutions were from inspiring English sources

To investigate alternative mechanisms by which A8 substitutions enhance activity, multiple substitutions were introduced.

For a number of residues multiple substitutions were created, which almost in all cases produced the same effect.

The T184, S202 or M250 ETV signature substitutions did not display significant resistance in the absence of LVDr changes, establishing that multiple substitutions were required for phenotypic resistance leading to virologic breakthrough on ETV.

Multiple substitutions were corrected using the Poisson distance model.

Trees were generated following gap exclusion and corrections for multiple substitutions were performed using the Kimura two-parameter substitution model.

The trees obtained with these different algorithms and with the neighbor joining algorithm (Felsenstein 1997) from Clustal, corrected for multiple substitutions, were essentially identical with respect to the branching order of the different phyla.

Kimura correction for multiple substitutions was applied [56].

For calculating cooperativity, the effect of multiple substitutions is measured directly (observed value).

The Jukes-Cantor correction for multiple substitutions was applied.

Kimura correction for multiple substitutions was applied [ 33].

The authors also point that the number of codons with multiple substitutions is not expected to be high.