Sentence examples for multiple substitutions that from inspiring English sources

This is likely to be the case, given that there are multiple substitutions that can cause changes in receptor-binding specificity and two sites where substitutions will result in loss of glycosylation: positions 154 and 156 (table S3).

More extensive, and multiple, substitutions that are designed on the known structures may more successfully explain the differences in activity of the yeast and horse ADHs.

Additionally, concatenating sequences from many genes may overcome the problem of multiple substitutions that cause the loss of phylogenetic information between cp lineages [ 30].

Any multiple substitutions that have occurred on the evolutionary pathway between the two sequences cause an underestimate of the corresponding pairwise difference, which violates orthogonality.

Two divergent copies of the rrn5 gene are present, although one is likely non-functional, exhibiting 3 substantial insertions (7, 9, and 16 bp) and multiple substitutions that greatly reduce the stability of the widely conserved 5S rRNA secondary structure (see below).

Additionally, concatenating sequences from many genes may overcome the problem of multiple substitutions that results in loss of phylogenetic information between chloroplast lineages (Lockhart et al. 1999) and can reduce "sampling errors due to substitutional noise" (Sanderson and Doyle 2001).

RNA secondary structure modeling of the nine sequences shows a high conservation of secondary structure with multiple base substitutions that maintain base pairing.

This is in contrast to copy number variation data and mutation data, i.e. single-base substitutions, short indels, or multiple base substitutions, that might be modeled better with multinomial or categorical distributions.

If the estimate of this parameter decays over time, the substitution model is likely to be underestimating the true number of multiple substitutions, such that it has poor performance.

Improved proteins often contain multiple and dispersed substitutions that act synergistically to improve enzyme properties and function.

However, they did not adjust for multiple amino acid substitutions that commonly occur within a single HLA-mismatch [ 11].