A seminal feature of hepatocellular carcinoma is the ability to produce multiple subpopulations of cells with diverse genetic, biochemical and immunological characteristics [ 3, 4].
In the initial diagnosis, breast cancers were known to consist of multiple subpopulations of cells with the characteristics of chromosome aberrations [ 30].
Primary neoplasms consist of multiple subpopulations of cells with heterogeneity in diverse properties, such as gene expression, karyotype, growth rate, antigenicity/immunogenicity, cell surface receptors, marker enzymes, sensitivity to different cytotoxic drugs, invasion, and metastasis [ 3, 4, 34].
An improved EP with multiple subpopulations and parallel search for solving OPF with non-smooth and non-convex generator fuel cost curves was proposed in [57].
Human pluripotent stem cells (hPSCs) exist in heterogeneous micro-environments with multiple subpopulations, convoluting fate-regulation analysis.
In a multi-objective optimization problem, fitness sharing is useful in stabilizing the multiple subpopulations that arise along with the Pareto optimal set and preventing excessive competition among distant population members.
However, most studies exploring the impact of ignoring spatial structure in stock assessments have developed population models with multiple subpopulations, rather than exploring the impact spatial dynamics may have on performance of non-spatially structured assessment methods.
It was important that MMP address multiple subpopulations of people living with HIV infection, including those receiving regular care and those who access care intermittently.
Motivation: High-throughput sequencing of tumor samples has shown that most tumors exhibit extensive intra-tumor heterogeneity, with multiple subpopulations of tumor cells containing different somatic mutations.
We recommend association mapping with multiple subpopulations having more than 100 lines (in F5 or F6 generation) before any other selection, except for the trait of interest, is placed on them.
