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In contrast to glioblastomas and the majority of paediatric brain tumours, which represent multiple subgroups with diverse genetic and epigenetic background27,28,29, recurrent genetic alterations in AT/RT are mainly restricted to the SMARCB1 gene, which is evolutionarily highly conserved3,4,5.
Recent genome wide analyses have identified multiple subgroups with differing outcomes [ 2, 3].
Breast cancer is a heterogeneous disease encompassing multiple subgroups with differing molecular signatures, prognoses, and responses to therapies.
Breast cancer is a heterogeneous disease composed of multiple subgroups with different molecular alterations, cellular composition, clinical behaviour, and response to treatment.
It is now clear that breast cancer is a heterogeneous disease of multiple subgroups with different molecular alterations, cellular composition, clinical behaviour, and response to treatment [ 7– 9].
Clinical studies of severe asthmatics have identified multiple subgroups with distinct clinical or inflammatory phenotypes that reflect different mechanisms of disease pathogenesis.
Similar(50)
There are multiple subgroups within these levels.
Similar results were noted in multiple subgroups and with the use of several different analytic methods.
This value was similar across multiple utility methods, each with its own theoretical strengths and weaknesses, as well as across multiple subgroups, and is consistent with the two previous small studies done using the TTO method.
The findings are in accordance with a recent study of Monaghan et al. in which multiple subgroups of vimentin+ cells with distinctive morphology were found in all layers of the bladder wall [ 26].
When interpreting our findings one must consider the low absolute number of patients as well as the fact that the results derived from the analysis of multiple subgroups, even though these were identified with a solid pathophysiological rationale.
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