Sentence examples for multiple subclones in from inspiring English sources

The presence of multiple subclones in an index biopsy may be necessary, but not sufficient, for relapse of localized prostate cancer, suggesting that evolution-aware biomarkers should be studied in prospective studies of low-risk tumors suitable for active surveillance.

The majority of patients with ATLL also had multiple subclones in their lymph nodes [ 6].

We also analyzed the existence of multiple subclones in PTCL using previous results evaluated by BAC aCGH [ 7].

The identification of multiple subclones in lymph nodes of PTCL, NOS as found in ATLL may further indicate the similarity between these diseases.

Thus, our finding of the presence of multiple subclones in PTCL, NOS and ATLL suggests that these two disease categories partly share common clinicopathological features.

In this study, we found that the majority of patients with PTCL, NOS with genomic aberrations had multiple subclones in their lymph nodes.

In this study, we investigated in detail whether PTCL, NOS with genomic aberrations also has multiple subclones as in ATLL by performing high-resolution oligo-array CGH (Agilent Technologies, CA) using a 44000 probe set.

The results showed that 11 (84.6%) of the 13 cases had a log2 ratio imbalance, suggesting that multiple subclones exist in PTCL, NOS with genomic aberrations.

The basic assumption adopted in CLImAT is that there is a single copy number for all tumor cells, which will not hold if multiple subclones exist in a tumor sample.

Multiple subclones were detected in 59% of patients, and specific subclonal architectures associate with adverse clinicopathological features.

In this study, we analyzed whether PTCL, NOS with genomic aberrations also has multiple subclones as found in ATLL by means of high-resolution oligo-array comparative genomic hybridization (CGH).