A similar mechanism of subcellular localization of protein fragments was recently described for Ral binding protein-1 (RalBproteinproteimplicatedted in Ras function [ 47], and other multiple functions localized to various subcellular regions including the nucleus, the actin cytoskeleton, and with the mitotic spindle and centrosome during mitosis [ 47].
Tomographic reconstructions of irregular objects such as subcellular regions often contain multiple copies of molecular complexes.
The α-actinins are known to be present in multiple subcellular compartments, including cell cell and cell-matrix contact sites, cellular protrusions and stress fiber dense regions [26].
Some drugs act on multiple subcellular targets.
The complex metabolic networks in plants are highly compartmentalized and biochemical steps of a single pathway can take place in multiple subcellular locations.
The most effective location for a particular inhibitory RNA is not necessarily predictable; thus these cassettes allow testing of the same RNA insert in multiple subcellular locations.
Disrupted-In-Schizophrenia-1 protein occurs in multiple subcellular compartments, which include the centrosome, microtubule fractions, postsynaptic densities, actin cytoskeletal fractions, the mitochondria, and the nucleus.
Ninety-one unique proteins were identified with the majority originating from the outer membrane, periplasm, and inner membrane, subcellular regions that comprise the Gram-negative bacterium cell envelope.
Second, as we have previously discussed, AGS3 localizes to multiple subcellular compartments.
We further studied the geometric features of the subcellular regions with relatively high RhoA activity after EGF stimulation.
