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Since RNASET2 is a protein with multiple subcellular localizations, the effects of overexpression and knockdown on mtRNA degradation could be indirect and be due to changes of its functions in other cellular compartments.
Given that AGS3 functions in a multitude of cellular activities associated with multiple subcellular localizations, it is very likely that additional AGS3-interacting proteins exist to control the function of AGS3 at specific subcellular compartments.
The differential expression and the multiple subcellular localizations of TCTEX1D4 in testicular cells may indicate that TCTEX1D4 has several functions.
Furthermore, LPGAT1 may have multiple subcellular localizations, and could therefore potentially have multiple functions in different cells or within the same cells [ 74].
Finally, all of these interactions and reactions may take place in diverse cellular locations, with many proteins having been identified as having multiple subcellular localizations [ 15].
If multiple subcellular localizations with equal Reliability Class were predicted for the isoforms of a gene, the subcellular localization of that gene was assigned 'Uncertain'.
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The DBMLoc database contains >10 000 proteins with multiple subcellular localization, which were experimentally determined or extracted from the literature.
Due to the existence of splice variants and the nature of protein sorting and trafficking, 8,970 proteins have multiple predicted subcellular localizations.
The results differ slightly from what we observed in the case of the predicted interactome for Arabidopsis (Geisler-Lee et al., 2007), in part due to the large number of proteins in our interactome that have multiple predicted subcellular localizations while in the Arabidopsis approach single subcellular localization was assigned to each protein through winner-takes-all strategy.
PARG exists as multiple isoforms with differing subcellular localizations, but the functional significance of these isoforms is uncertain.
We found nine shortest paths from EZR to ATF3 (Table 2) with all the lengths equal to 3. For better illustration, these proteins were also rearranged into multiple layers according to their subcellular localizations).
More suggestions(13)
multiple subcellular sites
multiple subcellular processes
multiple subcellular regions
multiple cellular localizations
multiple subcellular targets
multiple subcellular locations
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multiple subcellular relocalizations
multiple subcellular events
multiple subcellular organelles
multiple correct localizations
multiple subcellular fractions
multiple metastatic localizations
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