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Epsins contribute to multiple subcellular events that require membrane remodeling, and are best known for acting as clathrin adaptors during endocytosis (Horvath et al., 2007).
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Together, these results indicate that the progression of neuropathy in C22 mice is underlined by multiple ongoing pathogenic mechanisms, including intrinsic subcellular events within Schwann cells and extrinsic soluble factor-mediated processes, such as macrophage infiltration.
This complex situation indicates that multiple subcellular failure in selected cell populations is difficult to reconcile with a reductionistic scenario of a single causative cascade of events leading to non-motor symptoms in PD.
Some drugs act on multiple subcellular targets.
How control of subcellular events in single cells determines morphogenesis on the scale of the tissue is largely unresolved.
The herpes simplex virus (HSV) major tegument structural protein VP22 resides in multiple subcellular regions during productive infection.
To reveal how soybean responds to flooding and to analyze subcellular events and posttranslational modifications, researchers have used 2D gel-based and gel-free/label-free proteomic techniques.
Intravital microscopy is a powerful research tool that can provide insight into cellular and subcellular events that take place in organs in the body.
The complex metabolic networks in plants are highly compartmentalized and biochemical steps of a single pathway can take place in multiple subcellular locations.
The most effective location for a particular inhibitory RNA is not necessarily predictable; thus these cassettes allow testing of the same RNA insert in multiple subcellular locations.
Disrupted-In-Schizophrenia-1 protein occurs in multiple subcellular compartments, which include the centrosome, microtubule fractions, postsynaptic densities, actin cytoskeletal fractions, the mitochondria, and the nucleus.
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