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This approach takes advantage of covariance between multiple study phenotypes and therefore may be more powerful for detecting pleiotropic genes.
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Study multiple study guides.
GRIN2B was associated with MRI phenotypes in multiple studies using different methods (Ge et al. 2012; Kohannim et al. 2012a; Stein et al. 2010b).
Several genes (e.g., APOC1, FTO, GRIN2B, MAGI2, and TOMM40) were discovered to be associated with multiple phenotypes by multiple studies using different approaches, and these genes warrant further investigation and replication on other data sets.
Results: We transform gene expression profiles into binary gene set profiles by discretizing results of gene set enrichment analyses and apply a new iterative bi-clustering algorithm (iBBiG) to identify groups of gene sets that are coordinately associated with groups of phenotypes across multiple studies.
Alterations in several genes and pathways were identified as being linked to the luminal A/B phenotype in multiple studies.
There is some evidence that NK cells play a protective role in individuals exposed to HCV. 3 4 However, there is no consensus between multiple studies of NK cell receptor phenotype in chronic HCV infection.
56 Multiple studies have demonstrated that ALS and FTD phenotypes are associated with the C9ORF72 GGGGCC hexanucleotide repeat expansion.
Multiple studies have demonstrated that drug-resistant cells exhibited EMT phenotype (Wang et al, 2011; Mallini et al, 2014).
Definition of phenotypes and pathways demands very large datasets achieved by combining data from multiple studies.
The focus phenotypes are selected to strike a balance between those that are common to multiple studies and those that are specific to individual studies.
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