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A consistent, bundled methodology implemented at multiple study centers would standardize processes and allow comparison of outcomes, validation of the methodology, and benchmarking.
Standardized protocols were developed (Merlo et al. 2009) and applied to the collection of cord blood from multiple study centers.
The universal healthcare system in Ontario provides a unique opportunity to study long-term outcomes of unusual conditions across multiple study centers and for an entire population.
Key strengths of the present study relate to the harmonized protocols of the methodology, and the fact that cord blood was collected and processed using a common protocol (Merlo et al. 2009) in multiple study centers.
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Despite a historically stronger focus on medically-relevant viruses, recent years novel technologies brought forth increasing activities in the field of environmental virology, with multiple studies centered in marine and aquatic environments, as well as several extreme environments.
Overall, having one comprehensive trial registry for all trials and using a unique registration number would simplify the search for trials [ 29, 31, 34, 50], and would enable the differentiation between multiple studies and multi-center trials [ 29, 31, 36, 43].
This randomized, double-blind, placebo-controlled, multiple-dose, phase 1 study was conducted at four study centers in Japan.
The study centers on white dwarf stars.
Study multiple study guides.
Individuals in the highest quartile of DPP-IV were not at greater risk of diabetes (hazard ratio 0.88 [95% CI 0.62 1.24]) in Cox proportional hazards models adjusting for age, sex, race, study center, and multiple additional diabetes risk factors.
We suggest that larger cohort studies or multiple center studies are needed to validate whether acupuncture is another effective stimulation pattern to activate the cholinergic anti-inflammatory pathway.
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