Multiple studies have determined that IPSCs are very similar to ESCs in their pluripotency and capacity to differentiate[3] [5], and more recent studies have sought to determine whether IPSCs and their derivatives also show signs of cellular rejuvenation following adoption of the ESC-like phenotype[6] [10].
Multiple studies have determined minimum clinically important difference (MCID) thresholds for EuroQOL-5 Dimensions (EQ-5D) scores in lumbar fusion patients.
-Mentions that the woman cited above "was tested and had no sign of Lyme," but mentions nowhere in the article that multiple studies have determined that the two-tiered IDSA-recommended tests are less than 50percentt sensitive, meaning that they result in false negatives for at least half of people who have Lyme disease.
To investigate the role of maternal asthma in offspring asthma, we performed a meta-analysis of multiple studies to determine if a parent of origin effect exists.
Meta-analysis is a statistical procedure that can be used to synthesize evidence from multiple studies to determine the common effect when effect sizes are consistent, or to identify reasons for variation between studies when effects are inconsistent.
1 8 To limit the treatment burden associated with frequent anti-VEGF injections, combination regimens with macular laser photocoagulation and anti-VEGF drugs have been investigated in multiple studies to determine if they might result in fewer required interventions. 3 5–9 However, attempts to limit the number of injections have not produced comparable visual outcomes.
However, multiple studies have determined that TNF blockage increases total cholesterol levels (triglycerides, low-density lipoproteins and high-density lipoproteins) in RA patients, putting in doubt the level of efficacy of these treatments in reducing cardiovascular events in patients with autoimmune diseases such as RA [ 65].
Also, multiple studies have determined that the effects of deleterious mtDNA mutations might be exacerbated by mtDNA nucleotide changes that are not pathogenic per se and by unknown factors in nuclear genetic background, i.e. so-called modifier genes (Cai et al., 2008; Swalwell et al., 2008).
Multiple studies were performed determining the associations for baseline radiographic or clinical severity of OA [ 9, 13, 15, 21, 26, 27, 30, 34].
Multiple studies have previously determined small non-coding RNA candidates of species L. monocytogenes that were classified as intergenic sRNAs, antisense sRNAs, or cis-regulatory RNAs (including riboswitches) [ 35- 41].
