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TCDD causes specific tumors in mice (hepatocellular carcinoma, skin tumors, and lymphoma in multiple studies, as well as thyroid and lung tumors in single studies), rats (hepatocellular carcinoma, cholangiocarcinoma, and lung and oral cavity tumors in multiple studies, as well as tumors of the thyroid, skin, and uterus in single studies), and hamster (skin tumors in multiple studies).
We consciously attempted to choose those characteristics that reappeared in multiple studies as well as those originating from high-quality articles while being wary to the bias that the bulk of the research focused on large, successful projects.
I will now discuss a few approaches that allow us to control the FDR with multiple families and/or multiple studies, as well as studies with increasing set of hypothesis as those that may be mined from an open database.
The objective of establishing these committees is to avoid harassing individuals by inviting them to multiple studies as could be the case, for example, for individuals carrying a rare genetic variant, and ensure that ethical standards are respected [ 2, 7, 10].
The initial search revealed multiple studies as far back as 1970 that investigated physical performance measures of football players.
Elevated levels of survivin are significantly associated with poor outcome in multiple studies, as judged by a random effect model.
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Many of the additional studies characterize less than 100 single nucleotide polymorphisms (SNPs), often include multiple and correlated phenotypic measurements, and can include data from multiple-sites, multiple-studies, as well as multiple race/ethnicities.
Multiple previous studies as well as our data show that communication between emigrants and their families occurs frequently.
Regardless of which adjustments are chosen for our data, convincing evidence of a genetic effect ultimately requires multiple replication studies as well as detailed analysis of functional effects of each polymorphism.
Although multiple association studies as well as functional experiments have revealed that FTO is critical for obesity and 2DM, only one study with really small sample size has reported that FTO is assocaited with increased rifk for acute coronary syndrome, a severe form of CAD [ 29].
However, in the past 15 years, multiple cluster studies as well as scientific and technologic developments have affected cluster science and response (improvements in cancer registries, a federal initiative in environmental public health tracking, refinement of biomarker technology, cluster identification using geographic information systems software, and the emergence of the Internet).
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